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Burden of Disease Prevenar 13® Effectiveness Dosing Risk Prevention Important Safety Information Abbreviated Prescribing Information
Burden of DiseasePneumococcal disease remains the leading cause of vaccine-preventable death in children worldwide.2Clinical manifestations of pneumococcal disease include:
The WHO recommends including PCVs in childhood immunization programmes.7 *Based on the 2011 surveillance of notifiable disease cases among children <5 years of age reported to the Centers for Disease Control and Prevention. Policies for reporting notifiable disease cases can vary by disease or reporting jurisdiction.3Abbreviations:

AIDS, acquired immune deficiency syndrome; IPD, invasive pneumococcal disease; OM, otitis media; PCV, pneumococcal conjugate vaccine; WHO, World Health Organization.

  1. Egyptian drug authority Prevenar 13 leaflet approval date 7/4/2021, revision date November 2020.
  2. World Health Organization. Immunisation Coverage. Accessed April 4, 2023.
  3. Centers for Disease Control and Prevention. Summary of Notifiable Diseases, United States, 2011. MMWR Morb Mortal Wkly Rep. 2013;60(53):1-117.
  4. Grijalva CG, et al. Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis. Lancet. 2007;369(9568):1179-1186.
  5. Zhou F, et al. Health care utilization for pneumonia in young children after routine pneumococcal conjugate vaccine use in the United States. Arch Pediatr Adolesc Med. 2007;161(12):1162-1168.
  6. Rodgers GL, et al. Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccines. Vaccine. 2009;27(29):3802-3810.
  7. World Health Organization. Wkly Epidemiol Rec. 2012;87(14):129-144.

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