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Unmet Need Molecular Structure Guidelines Study design Efficacy Safety Dosing and Therapy Management Summary Important Safety Information Abbreviated Prescribing Information
Unmet Need

Options are limited when your patient with ALK+ advanced NSCLC progresses2

The two major challenges with Anaplastic Lymphoma Kinase (ALK) TKIs are:

















Abbreviations: ALK, Anaplastic lymphoma kinase; CNS, Central nervous system; NSCLC, Non-small cell lung cancer; TKI, Tyrosine kinase inhibitor

References:Lorbrena™ EDA leaflet approval date 26/4/2021.Solomon BJ, Besse B, Bauer TM, et al. Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study. Lancet Oncol. 2018;19(12):1654–1667.Gainor JF, Dardaei L, Yoda S, et al. Molecular mechanisms of resistance to first- and second-generation ALK inhibitors in ALK-rearranged lung cancer. Cancer Discov. 2016;6(10):1118–1133. Lin JJ, Riely GJ, Shaw AT. Targeting ALK: precision medicine takes on drug resistance. Cancer Discov. 2017;7(2):137–155.

MOH Approval No: HF0098OA54/062022
Invalidation date: 12/06/2024

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