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Flexible dosing
On demand treatment & Prophylaxis
Dosing optimisation
Administration, reconstitution and storage
Dosing that’s as individual as your patients1
Flexible dosing
BeneFIX comes in a range of vial sizes offering a flexible dosing for your patients1
BeneFIX offers frequent, flexible dosing1
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BeneFIX comes in a range of vial sizes, so you can individualize factor IX coverage for your patients1 |
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BeneFIX can be given as on-demand treatment or as prophylaxis1 |
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BeneFIX offers patients storage flexibility through room temperature from 2°C to 30°C1 |
FIX: factor IX.
Reference:
BeneFIX can be given as on-demand treatment or as prophylaxis
On demand treatment1
The calculation of the required dose of BeneFIX can be based on the finding that one unit of factor IX activity per kg body weight is expected to increase the circulating level of factor IX, an average of 0.8 IU/dL (range from 0.4 to 1.4 IU/dL) in patients ≥12 years.1
The required dose is determined using the following formula: number of factor IX IU required = body weight (in kg) X desired factor IX increase (%) or (IU/dL) X reciprocal of observed recovery.1
The amount to be administered and the frequency of administration should always be oriented to the clinical effectiveness in the individual case.!
In the case of the following haemorrhagic events, the factor IX activity should not fall below the given plasma activity levels (in percentage of normal or in IU/dL) in the corresponding period. The following table can be used to guide dosing in bleeding episodes and surgery:1
Prophylaxis
Long term Prophylaxis Treatment
FIX: factor IX; IU: international unit; PTP: previously treated patient.
Reference:
Dosing Optimisation with BeneFIX
Achieving Medicines Optimisation with BeneFIX
What is medicines optimisation and what are the benefits?
The goal of medicines optimisation is to help patients to:2
How can BeneFIX allow for improved medicines optimisation?
FIX: factor IX.
References:
Administration1
BeneFIX is administered by intravenous infusion after reconstitution of the lyophilised powder for solution for injection with sterile 0.234% sodium chloride solution.
BeneFIX should be administered at a slow infusion rate. In most of the cases, an infusion rate of up to 4 mL per minute has been used. The rate of administration should be determined by the patient’s comfort level.
If any suspected hypersensitivity reaction takes place that is thought to be related to the administration of BeneFIX, the rate of infusion should be decreased or the infusion stopped.
Contents of the container1
Special precautions for storage1
FIX: factor IX.
Reference:
Approval No. : BV0098A2259/032022
Invalidation Date: 17/02/2025 |
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